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Relationships between the sequence of α-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity
To investigate the α-synuclein protein and its role in Parkinson’s disease, we screened a library of random point mutants both in vitro and in yeast to find variants in an unbiased way that could help us understand the sequence-phenotype relationship. We developed a rapid purification method that al...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868670/ https://ncbi.nlm.nih.gov/pubmed/17222866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.044 |
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