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Sensitivity of secondary structure propensities to sequence differences between α- and γ-synuclein: Implications for fibrillation

The synucleins are a family of intrinsically disordered proteins involved in various human diseases. α-Synuclein has been extensively characterized due to its role in Parkinson's disease where it forms intracellular aggregates, while γ-synuclein is overexpressed in a majority of late-stage brea...

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Main Authors: Marsh, Joseph A., Singh, Vinay K., Jia, Zongchao, Forman-Kay, Julie D.
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2242444/
https://ncbi.nlm.nih.gov/pubmed/17088319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062465306
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