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A sensitive assay reveals structural requirements for α-synuclein fibril growth

The accumulation of α-synuclein (α-syn) fibrils in neuronal inclusions is the defining pathological process in Parkinson's disease (PD). A pathogenic role for α-syn fibril accumulation is supported by the identification of dominantly inherited α-syn (SNCA) gene mutations in rare cases of famili...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dhavale, Dhruva D., Tsai, Christina, Bagchi, Devika P., Engel, Laura A., Sarezky, Jonathan, Kotzbauer, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454090/
https://ncbi.nlm.nih.gov/pubmed/28373279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.767053
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