Synthesis and in vitro evaluation of α-synuclein ligands

Accumulation of misfolded α-synuclein in Lewy bodies and Lewy neurites is the pathological hallmark of Parkinson’s Disease (PD). To identify ligands having high binding potency toward aggregated α-synuclein, we synthesized a series of phenothiazine derivatives and assessed their binding affinity to...

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Bibliographic Details
Main Authors: Yu, Lihai, Cui, Jinquan, Padakanti, Prashanth K., Engel, Laura, Bagchi, Devika P., Kotzbauer, Paul T., Tu, Zhude
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401268/
https://ncbi.nlm.nih.gov/pubmed/22789706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.023
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