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Design, synthesis, and in vitro evaluation of quinolinyl analogues for α-synuclein aggregation
Here we report the synthesis and in vitro evaluation of 25 new quinolinyl analogues for α-synuclein aggregates. Three lead compounds were subsequently labeled with carbon-11 or fluorine-18 to directly assess their potency in a direct radioactive competitive binding assay ng both α-synuclein fibrils...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5870887/ https://ncbi.nlm.nih.gov/pubmed/29482941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.02.031 |
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