Design, Synthesis and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

A series of 3-(benzilidine)indolin-2-one derivatives were synthesized and evaluated for their in vitro binding to alpha synuclein (α-syn), beta amyloid (Aβ), and tau fibrils. Compounds with a single double bond in the 3-position had only a modest affinity for α-syn and no selectivity for α-syn versu...

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Pubblicato in:J Med Chem
Autori principali: Chu, Wenhua, Zhou, Dong, Gaba, Vrinda, Liu, Jialu, Li, Shihong, Peng, Xin, Xu, Jinbin, Dhavale, Dhruva, Bagchi, Devika P., d’Avignon, André, Shakerdge, Naomi B., Bacskai, Brian J., Tu, Zhude, Kotzbauer, Paul T., Mach, Robert H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624220/
https://ncbi.nlm.nih.gov/pubmed/26177091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00571
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