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Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization

α-Synuclein is the major component of pathological inclusions characteristic of diseases like Parkinson’s disease, dementia with Lewy bodies, and multiple systems atrophy. A role for α-synuclein in neurodegenerative diseases is further supported by point mutations and duplication/triplication of the...

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Detalhes bibliográficos
Main Authors: Waxman, Elisa A., Mazzulli, Joseph R., Giasson, Benoit I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758333/
https://ncbi.nlm.nih.gov/pubmed/19722699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900539p
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