Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

Por Uchihara, Toshiki, Giasson, Benoit I.
Publicado no Acta Neuropathol (2015)

Identification of Compounds that Inhibit the Kinase Activity of Leucine-rich Repeat Kinase 2

Por Covy, Jason P., Giasson, Benoit I.
Publicado em 2008

The E163K DJ-1 Mutant Shows Specific Antioxidant Deficiency

Por Ramsey, Chenere P., Giasson, Benoit I.
Publicado em 2008

Molecular Mechanisms of α-Synuclein Neurodegeneration

Por Waxman, Elisa A., Giasson, Benoit I.
Publicado em 2008

A Novel, High-Efficiency Cellular Model of Fibrillar α-Synuclein Inclusions and the Examination of Mutations that Inhibit Amyloid Formation

Por Waxman, Elisa A., Giasson, Benoit I.
Publicado em 2010

IDENTIFICATION AND CHARACTERIZATION OF A NOVEL ENDOGENOUS MURINE PARKIN MUTATION

Por Ramsey, Chenere P., Giasson, Benoit I.
Publicado em 2010

Specificity and Regulation of Casein Kinase/Mediated Phosphorylation of α-Synuclein

Por Waxman, Elisa A., Giasson, Benoit I.
Publicado em 2008

L10P and P158DEL DJ-1 Mutations Cause Protein Instability, Aggregation, and Dimerization Impairments

Por Ramsey, Chenere P., Giasson, Benoit I.
Publicado em 2010

The G2019S Pathogenic Mutation Disrupts Sensitivity of Leucine-Rich Repeat Kinase 2 to Manganese Kinase Inhibition

Por Covy, Jason P., Giasson, Benoit I.
Publicado em 2010

Induction of Intracellular Tau Aggregation Is Promoted by α-Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

Por Waxman, Elisa A., Giasson, Benoit I.
Publicado em 2011

α-Synuclein, Leucine-Rich Repeat Kinase-2, and Manganese in the Pathogenesis of Parkinson Disease

Por Covy, Jason P., Giasson, Benoit I.
Publicado em 2011

Does a prion-like mechanism play a major role in the apparent spread of α-synuclein pathology?

Por Sacino, Amanda N, Giasson, Benoit I
Publicado em 2012

The A53E α-Synuclein Pathological Mutation Demonstrates Reduced Aggregation Propensity in vitro and in Cell Culture

Por Rutherford, Nicola J, Giasson, Benoit I
Publicado no Neurosci Lett (2015)

Characterization of kinases involved in the phosphorylation of aggregated α-synuclein

Por Waxman, Elisa A., Giasson, Benoit I.
Publicado no J Neurosci Res (2010)

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

Por Rutherford, Nicola J., Brooks, Mieu, Giasson, Benoit I.
Publicado no Acta Neuropathol Commun (2016)

Characterization of antibodies that selectively detect α-synuclein in pathological inclusions

Por Waxman, Elisa A., Giasson, Benoit I., Duda, John E.
Publicado em 2008

Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization

Por Waxman, Elisa A., Mazzulli, Joseph R., Giasson, Benoit I.
Publicado em 2009

Residue Glu83 Plays a Major Role in Negatively Regulating α-Synuclein Amyloid Formation

Por Waxman, Elisa A., Emmer, Kristel L., Giasson, Benoit I.
Publicado em 2009

DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

Por Hao, Ling-Yang, Giasson, Benoit I., Bonini, Nancy M.
Publicado em 2010

Studies of Protein Aggregation in A53T α-Synuclein Transgenic, Tg2576 Transgenic, and P246L Presenilin-1 Knock-in Cross Bred Mice

Por Emmer, Kristel L., Covy, Jason P., Giasson, Benoit I.
Publicado em 2011