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Identification of Compounds that Inhibit the Kinase Activity of Leucine-rich Repeat Kinase 2
Mutations in leucine-repeat rich kinase-2 (LRRK2) are the most common known cause of late-onset Parkinson's disease. In this study, a novel system to purify active recombinant LRRK2 expressed in mammalian cells was generated. This recombinant enzyme was used to characterize the specificity of L...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633649/ https://ncbi.nlm.nih.gov/pubmed/19027715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.11.048 |
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