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Identification of Compounds that Inhibit the Kinase Activity of Leucine-rich Repeat Kinase 2

Mutations in leucine-repeat rich kinase-2 (LRRK2) are the most common known cause of late-onset Parkinson's disease. In this study, a novel system to purify active recombinant LRRK2 expressed in mammalian cells was generated. This recombinant enzyme was used to characterize the specificity of L...

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書誌詳細
主要な著者: Covy, Jason P., Giasson, Benoit I.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633649/
https://ncbi.nlm.nih.gov/pubmed/19027715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.11.048
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