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Leucine-rich Repeat Kinase 2 Expression Leads to Aggresome Formation that is not Associated with α-Synuclein Inclusions

Mutations in leucine-rich repeat kinase-2 (LRRK2) are the most common known cause of Parkinson disease (PD), but how this protein results in the pathobiology of PD is unknown. Moreover, there is variability in pathology among cases and α-synuclein (α-syn) neuronal inclusions are often present but wh...

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Библиографические подробности
Главные авторы: Waxman, Elisa A., Covy, Jason P., Bukh, Irene, Li, Xiaojie, Dawson, Ted M., Giasson, Benoit I.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722758/
https://ncbi.nlm.nih.gov/pubmed/19535993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181aaf4fd
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