The A53E α-Synuclein Pathological Mutation Demonstrates Reduced Aggregation Propensity in vitro and in Cell Culture

Por Rutherford, Nicola J, Giasson, Benoit I
Publicado no Neurosci Lett (2015)

Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes

Por Rutherford, Nicola J., Brooks, Mieu, Giasson, Benoit I.
Publicado no Acta Neuropathol Commun (2016)

Voxelotor (GBT440) produces interference in measurements of hemoglobin S

Por Rutherford, Nicola J., Thoren, Katie L., Shajani-Yi, Zahra, Colby, Jennifer M.
Publicado no Clin Chim Acta (2018)

Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice

Por Rutherford, Nicola J, Dhillon, Jess-Karan S, Riffe, Cara J, Howard, Jasie K, Brooks, Mieu, Giasson, Benoit I
Publicado no Hum Mol Genet (2017)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Por Sorrentino, Zachary A., Brooks, Mieu M.T., Hudson, Vincent, Rutherford, Nicola J., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Publicado no Mol Neurodegener (2017)

Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A

Por Aoki, Naoya, Murray, Melissa E., Ogaki, Kotaro, Fujioka, Shinsuke, Rutherford, Nicola J., Rademakers, Rosa, Ross, Owen A., Dickson, Dennis W.
Publicado no Acta Neuropathol (2014)

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Por Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Publicado no J Virol (2017)

Prion-like transmission of α-synuclein pathology in the context of an NFL null background

Por Rutherford, Nicola J, Brooks, Mieu, Riffe, Cara J, Gorion, Kimberly-Marie M, Howard, Jasie K, Dhillon, Jess-Karan S, Giasson, Benoit I
Publicado no Neurosci Lett (2017)

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice

Por Rutherford, Nicola J., Sacino, Amanda N., Brooks, Mieu, Ceballos-Diaz, Carolina, Ladd, Thomas B., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I.
Publicado no Mol Neurodegener (2015)

C9ORF72 hexanucleotide repeat expansions in patients with ALS from the Coriell Cell Repository

Por Rutherford, Nicola J., DeJesus- Hernandez, Mariely, Baker, Matt C., Kryston, Thomas B., Brown, Patricia E., Lomen-Hoerth, Catherine, Boylan, Kevin, Wszolek, Zbigniew K., Rademakers, Rosa
Publicado em 2012

Differential clinicopathologic and Genetic features of late-onset amnestic dementias

Por Murray, Melissa E., Cannon, Ashley, Graff-Radford, Neill R., Liesinger, Amanda M., Rutherford, Nicola J., Ross, Owen A., Duara, Ranjan, Carrasquillo, Minerva M., Rademakers, Rosa, Dickson, Dennis W.
Publicado no Acta Neuropathol (2014)

Clinical and pathological features of amyotrophic lateral sclerosis caused by mutation in the C9ORF72 gene on chromosome 9p

Por Stewart, Heather, Rutherford, Nicola J., Briemberg, Hannah, Krieger, Charles, Cashman, Neil, Fabros, Marife, Baker, Matt, Fok, Alice, DeJesus-Hernandez, Mariely, Eisen, Andrew, Rademakers, Rosa, Mackenzie, Ian R. A.
Publicado em 2012

Pathogenicity of exonic indels in fused in sarcoma in amyotrophic lateral sclerosis

Por Rutherford, Nicola J., Finch, NiCole A., DeJesus-Hernandez, Mariely, Crook, Richard J.P., Lomen-Hoerth, Catherine, Wszolek, Zbigniew K., Uitti, Ryan J., Graff-Radford, Neill R., Rademakers, Rosa
Publicado em 2010

Tau Pathology in Frontotemporal Lobar Degeneration with C9ORF72 Hexanucleotide Repeat Expansion

Por Bieniek, Kevin F., Murray, Melissa E., Rutherford, Nicola J., Castanedes-Casey, Monica, DeJesus-Hernandez, Mariely, Liesinger, Amanda M., Baker, Matthew C., Boylan, Kevin B., Rademakers, Rosa, Dickson, Dennis W.
Publicado em 2012

Progranulin protein levels are differently regulated in plasma and CSF

Por Nicholson, Alexandra M., Finch, NiCole A., Thomas, Colleen S., Wojtas, Aleksandra, Rutherford, Nicola J., Mielke, Michelle M., Roberts, Rosebud O., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Rademakers, Rosa
Publicado em 2014

Motor Neuron Loss and Neuroinflammation in a Model of α-Synuclein-induced Neurodegeneration

Por Sorrentino, Zachary A, Xia, Yuxing, Funk, Cory, Riffe, Cara J, Rutherford, Nicola J, Ceballos Diaz, Carolina, Sacino, Amanda N, Price, Nathan D, Golde, Todd E, Giasson, Benoit I, Chakrabarty, Paramita
Publicado no Neurobiol Dis (2018)

Clinicopathologic variability of the GRN A9D mutation, including amyotrophic lateral sclerosis

Por Cannon, Ashley, Fujioka, Shinsuke, Rutherford, Nicola J., Ferman, Tanis J., Broderick, Daniel F., Boylan, Kevin B., Graff-Radford, Neill R., Uitti, Ryan J., Rademakers, Rosa, Wszolek, Zbigniew K., Dickson, Dennis W.
Publicado em 2013

Unbiased Screen Reveals Ubiquilin-1 and -2 Highly Associated with Huntingtin Inclusions

Por Rutherford, Nicola J., Lewis, Jada, Clippinger, Amy K., Thomas, Michael A., Adamson, Jennifer, Cruz, Pedro E., Cannon, Ashley, Xu, Guilian, Golde, Todd E., Shaw, Gerry, Borchelt, David R., Giasson, Benoit I.
Publicado em 2013

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease

Por Rutherford, Nicola J., Carrasquillo, Minerva M., Li, Ma, Bisceglio, Gina, Menke, Joshua, Josephs, Keith A., Parisi, Joseph E., Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Dickson, Dennis W., Rademakers, Rosa
Publicado em 2012

Clinical and neuropathologic heterogeneity of c9FTD/ALS associated with hexanucleotide repeat expansion in C9ORF72

Por Murray, Melissa E., DeJesus-Hernandez, Mariely, Rutherford, Nicola J., Baker, Matt, Duara, Ranjan, Graff-Radford, Neill R., Wszolek, Zbigniew K., Ferman, Tanis, Josephs, Keith A., Boylan, Kevin B., Rademakers, Rosa, Dickson, Dennis W.
Publicado em 2011