Phenotypic diversity in ALS and the role of poly-conformational protein misfolding

Por Ayers, Jacob I., Borchelt, David R.
Publicado no Acta Neuropathol (2020)

Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism

Por Ayers, Jacob I., Kincaid, Anthony E., Bartz, Jason C.
Publicado em 2009

Prion-like Spreading in Tauopathies

Por Ayers, Jacob I., Giasson, Benoit I., Borchelt, David R.
Publicado no Biol Psychiatry (2017)

Coinfecting Prion Strains Compete for a Limiting Cellular Resource

Por Shikiya, Ronald A., Ayers, Jacob I., Schutt, Charles R., Kincaid, Anthony E., Bartz, Jason C.
Publicado em 2010

Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases

Por Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P John, Borchelt, David R
Publicado em 2014

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

Por Ayers, Jacob I., Fromholt, Susan E., O’Neal, Veronica M., Diamond, Jeffrey H., Borchelt, David R.
Publicado no Acta Neuropathol (2015)

Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Por Crosby, Keith, Crown, Anthony M., Roberts, Brittany L., Brown, Hilda, Ayers, Jacob I., Borchelt, David R.
Publicado no PLoS One (2018)

The Strain-Encoded Relationship between PrP(Sc) Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Por Ayers, Jacob I., Schutt, Charles R., Shikiya, Ronald A., Aguzzi, Adriano, Kincaid, Anthony E., Bartz, Jason C.
Publicado em 2011

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice

Por Xu, Guilian, Ayers, Jacob I., Roberts, Brittany L., Brown, Hilda, Fromholt, Susan, Green, Cameron, Borchelt, David R.
Publicado no Hum Mol Genet (2015)

Lysine acylation in superoxide dismutase-1 electrostatically inhibits formation of fibrils with prion-like seeding

Por Rasouli, Sanaz, Abdolvahabi, Alireza, Croom, Corbin M., Plewman, Devon L., Shi, Yunhua, Ayers, Jacob I., Shaw, Bryan F.
Publicado no J Biol Chem (2017)

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Por Crown, Anthony M., Roberts, Brittany L., Crosby, Keith, Brown, Hilda, Ayers, Jacob I., Hart, P. John, Borchelt, David R.
Publicado no G3 (Bethesda) (2019)

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Por Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Publicado no J Virol (2017)

Prion Interference Is Due to a Reduction in Strain-Specific PrP(Sc) Levels

Por Bartz, Jason C., Kramer, Michelle L., Sheehan, Meghan H., Hutter, Jessica A. L., Ayers, Jacob I., Bessen, Richard A., Kincaid, Anthony E.
Publicado em 2007

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation

Por Xu, Guilian, Fromholt, Susan, Ayers, Jacob I., Brown, Hilda, Siemienski, Zoe, Crosby, Keith W., Mayer, Christopher A., Janus, Christopher, Borchelt, David R.
Publicado no J Neurochem (2015)

Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS

Por Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.
Publicado no Acta Neuropathol (2016)

Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Por Ayers, Jacob I., Riffe, Cara J., Sorrentino, Zachary A., Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P. John, Giasson, Benoit I.
Publicado no J Virol (2018)

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Por Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.
Publicado no PLoS One (2020)

Relationship between mutant SOD1 maturation and inclusion formation in cell models

Por Ayers, Jacob I., McMahon, Benjamin, Gill, Sabrina, Lelie, Herman L., Fromholt, Susan, Brown, Hilda, Valentine, Joan Selverstone, Whitelegge, Julian P., Borchelt, David R.
Publicado no J Neurochem (2016)

Non-prion type transmission in A53T α-synuclein transgenic mice: A normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

Por Sacino, Amanda N., Ayers, Jacob I., Brooks, Mieu M.T., Chakrabarty, Paramita, Hudson, Vincent J., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I., Borchelt, David R.
Publicado no Acta Neuropathol (2015)

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons

Por Osking, Zachary, Ayers, Jacob I., Hildebrandt, Ryan, Skruber, Kristen, Brown, Hilda, Ryu, Daniel, Eukovich, Amanda R., Golde, Todd E., Borchelt, David R., Read, Tracy-Ann, Vitriol, Eric A.
Publicado no iScience (2018)