Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts

Misfolded alpha-synuclein (αS) may exhibit a number of characteristics similar to those of the prion protein, including the apparent ability to spread along neuroanatomical connections. The demonstration for this mechanism of spread is largely based on the intracerebral injections of preaggregated α...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Ayers, Jacob I., Riffe, Cara J., Sorrentino, Zachary A., Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P. John, Giasson, Benoit I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6146706/
https://ncbi.nlm.nih.gov/pubmed/29976670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00586-18
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