Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice

Parkinson’s disease (PD) is one of many neurodegenerative diseases termed synucleinopathies, neuropathologically defined by inclusions containing aggregated α-synuclein (αS). αS gene (SNCA) mutations can directly cause autosomal dominant PD. In vitro studies demonstrated that SNCA missense mutations...

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Udgivet i:Hum Mol Genet
Main Authors: Rutherford, Nicola J, Dhillon, Jess-Karan S, Riffe, Cara J, Howard, Jasie K, Brooks, Mieu, Giasson, Benoit I
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886210/
https://ncbi.nlm.nih.gov/pubmed/29036344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx371
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