Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Misfolded α-synuclein (αS) is hypothesized to spread throughout the central nervous system (CNS) by neuronal connectivity leading to widespread pathology. Increasing evidence indicates that it also has the potential to invade the CNS via peripheral nerves in a prion-like manner. On the basis of the...

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Publié dans:J Virol
Auteurs principaux: Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215322/
https://ncbi.nlm.nih.gov/pubmed/27852849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02095-16
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