Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Misfolded α-synuclein (αS) is hypothesized to spread throughout the central nervous system (CNS) by neuronal connectivity leading to widespread pathology. Increasing evidence indicates that it also has the potential to invade the CNS via peripheral nerves in a prion-like manner. On the basis of the...

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Xehetasun bibliografikoak
Argitaratua izan da:J Virol
Egile Nagusiak: Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2017
Gaiak:
Prions
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215322/
https://ncbi.nlm.nih.gov/pubmed/27852849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02095-16
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