Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Misfolded α-synuclein (αS) is hypothesized to spread throughout the central nervous system (CNS) by neuronal connectivity leading to widespread pathology. Increasing evidence indicates that it also has the potential to invade the CNS via peripheral nerves in a prion-like manner. On the basis of the...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Ayers, Jacob I., Brooks, Mieu M., Rutherford, Nicola J., Howard, Jasie K., Sorrentino, Zachary A., Riffe, Cara J., Giasson, Benoit I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
Assuntos:
Prions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215322/
https://ncbi.nlm.nih.gov/pubmed/27852849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02095-16
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