Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using either in vitro polymerized αS fibrils or in vivo derived lysates containing αS aggregates...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Dhillon, Jess-Karan S., Trejo-Lopez, Jorge A., Riffe, Cara, Levites, Yona, Sacino, Amanda N., Borchelt, David R., Yachnis, Anthony Y., Giasson, Benoit I.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526622/
https://ncbi.nlm.nih.gov/pubmed/31109378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0733-3
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