Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using either in vitro polymerized αS fibrils or in vivo derived lysates containing αS aggregates...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Dhillon, Jess-Karan S., Trejo-Lopez, Jorge A., Riffe, Cara, Levites, Yona, Sacino, Amanda N., Borchelt, David R., Yachnis, Anthony Y., Giasson, Benoit I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526622/
https://ncbi.nlm.nih.gov/pubmed/31109378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0733-3
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