Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using either in vitro polymerized αS fibrils or in vivo derived lysates containing αS aggregates...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Dhillon, Jess-Karan S., Trejo-Lopez, Jorge A., Riffe, Cara, Levites, Yona, Sacino, Amanda N., Borchelt, David R., Yachnis, Anthony Y., Giasson, Benoit I.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6526622/
https://ncbi.nlm.nih.gov/pubmed/31109378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0733-3
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