Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

BACKGROUND: Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfer and, i...

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Publicado en:Mol Neurodegener
Autores principales: Sorrentino, Zachary A., Brooks, Mieu M.T., Hudson, Vincent, Rutherford, Nicola J., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5447308/
https://ncbi.nlm.nih.gov/pubmed/28552073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0182-z
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