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Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

BACKGROUND: Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn seeds followed by seeding of endogenous αSyn. Though it is well known that αSyn...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Koller, Emily J., Brooks, Mieu M. T., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210310/
https://ncbi.nlm.nih.gov/pubmed/28049533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0142-z
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