Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

BACKGROUND: Cell-to-cell transmission of α-synuclein (αSyn) is hypothesized to play an important role in disease progression in synucleinopathies. This process involves cellular uptake of extracellular amyloidogenic αSyn seeds followed by seeding of endogenous αSyn. Though it is well known that αSyn...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Koller, Emily J., Brooks, Mieu M. T., Golde, Todd E., Giasson, Benoit I., Chakrabarty, Paramita
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210310/
https://ncbi.nlm.nih.gov/pubmed/28049533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0142-z
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