Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

BACKGROUND: α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson’s disease. Aberrant aggregation of αS also is associated with cellular demise in multiple neurologic disorders collectively referred to as synucleinopathies. Recent...

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Autores principales: Sacino, Amanda N, Brooks, Mieu, McGarvey, Nicholas H, McKinney, Alex B, Thomas, Michael A, Levites, Yona, Ran, Yong, Golde, Todd E, Giasson, Benoit I
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893388/
https://ncbi.nlm.nih.gov/pubmed/24252149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-38
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