Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

To further evaluate the parameters whereby intracerebral administration of recombinant α-synuclein (αS) induces pathological phenotypes in mice, we conducted a series of studies where αS fibrils were injected into the brains of M83 (A53T) and M47 (E46K) αS transgenic (Tg) mice, and non-transgenic (n...

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Détails bibliographiques
Publié dans:Acta Neuropathol
Auteurs principaux: Sacino, Amanda N., Brooks, Mieu, Thomas, Michael A., McKinney, Alex B., McGarvey, Nicholas H., Rutherford, Nicola L., Ceballos-Diaz, Carolina, Robertson, Janice, Golde, Todd E., Giasson, Benoit I.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4869357/
https://ncbi.nlm.nih.gov/pubmed/24659240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-014-1268-0
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