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Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology

Progression of α-synuclein inclusion pathology may occur through cycles of release and uptake of α-synuclein aggregates, which induce additional intracellular α-synuclein inclusion pathology. This process may explain i) the presence of α-synuclein inclusion pathology in grafted cells in human brains...

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Vydáno v:J Neurochem
Hlavní autoři: Sacino, Amanda N., Brooks, Mieu My Thi, Chakrabarty, Paramita, Saha, Kaustuv, Khoshbouei, Habibeh, Golde, Todd E., Giasson, Benoit I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452425/
https://ncbi.nlm.nih.gov/pubmed/27424880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13743
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