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Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases
Greater than 160 missense mutations in copper-zinc superoxide dismutase-1 (SOD1) can cause amyotrophic lateral sclerosis (ALS). These mutations produce conformational changes that reveal novel antibody binding epitopes. A monoclonal antibody, clone C4F6 - raised against the ALS variant G93A of SOD1,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035506/ https://ncbi.nlm.nih.gov/pubmed/24887207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-55 |
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