The Strain-Encoded Relationship between PrP(Sc) Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Prion strains are characterized by differences in the outcome of disease, most notably incubation period and neuropathological features. While it is established that the disease specific isoform of the prion protein, PrP(Sc), is an essential component of the infectious agent, the strain-specific rel...

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Bibliografiske detaljer
Main Authors: Ayers, Jacob I., Schutt, Charles R., Shikiya, Ronald A., Aguzzi, Adriano, Kincaid, Anthony E., Bartz, Jason C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060105/
https://ncbi.nlm.nih.gov/pubmed/21437239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001317
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