Identifying Key Components of the PrP(C)-PrP(Sc) Replicative Interface

In prion disease, direct interaction between the cellular prion protein (PrP(C)) and its misfolded disease-associated conformer PrP(Sc) is a crucial, although poorly understood step promoting the formation of nascent PrP(Sc) and prion infectivity. Recently, we hypothesized that three regions of PrP...

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Autors principals: Abalos, Gil C., Cruite, Justin T., Bellon, Anne, Hemmers, Saskia, Akagi, Junya, Mastrianni, James A., Williamson, R. Anthony, Solforosi, Laura
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590689/
https://ncbi.nlm.nih.gov/pubmed/18826953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804475200
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