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Identifying Key Components of the PrP(C)-PrP(Sc) Replicative Interface
In prion disease, direct interaction between the cellular prion protein (PrP(C)) and its misfolded disease-associated conformer PrP(Sc) is a crucial, although poorly understood step promoting the formation of nascent PrP(Sc) and prion infectivity. Recently, we hypothesized that three regions of PrP...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590689/ https://ncbi.nlm.nih.gov/pubmed/18826953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804475200 |
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