Modulation of Glycosaminoglycans Affects PrP(Sc) Metabolism but Does Not Block PrP(Sc) Uptake

Mammalian prions are unconventional infectious agents composed primarily of the misfolded aggregated host prion protein PrP, termed PrP(Sc). Prions propagate by the recruitment and conformational conversion of cellular prion protein into abnormal prion aggregates on the cell surface or along the end...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wolf, Hanna, Graßmann, Andrea, Bester, Romina, Hossinger, André, Möhl, Christoph, Paulsen, Lydia, Groschup, Martin H., Schätzl, Hermann, Vorberg, Ina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Prions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577896/
https://ncbi.nlm.nih.gov/pubmed/26202247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01276-15
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