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Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation

The infectious agent in prion diseases consists of an aberrantly folded isoform of the cellular prion protein (PrP(c)), termed PrP(Sc), which accumulates in brains of affected individuals. Studies on prion-infected cultured cells indicate that cellular cholesterol homeostasis influences PrP(Sc) prop...

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Detalhes bibliográficos
Main Authors: Gilch, Sabine, Bach, Christian, Lutzny, Gloria, Vorberg, Ina, Schätzl, Hermann M.
Formato: Artigo
Idioma:Inglês
Publicado em: SP Birkhäuser Verlag Basel 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777232/
https://ncbi.nlm.nih.gov/pubmed/19823766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-009-0158-4
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