Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...

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Bibliografiska uppgifter
Huvudupphovsmän: Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC149175/
https://ncbi.nlm.nih.gov/pubmed/11483499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.15.3957
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