Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...

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Pubblicato in:	EMBO J
Autori principali:	Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.3957
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