Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication

The cellular form of the Prion protein (PrP(C)) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Eμ enha...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Raeber, Alex J., Sailer, Andreas, Hegyi, Ivan, Klein, Michael A., Rülicke, Thomas, Fischer, Marek, Brandner, Sebastian, Aguzzi, Adriano, Weissmann, Charles
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1999
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22407/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097150/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3987
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