Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synt...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaneko, K, Peretz, D, Pan, K M, Blochberger, T C, Wille, H, Gabizon, R, Griffith, O H, Cohen, F E, Baldwin, M A, Prusiner, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11160
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