Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synt...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Kaneko, K, Peretz, D, Pan, K M, Blochberger, T C, Wille, H, Gabizon, R, Griffith, O H, Cohen, F E, Baldwin, M A, Prusiner, S B
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40591/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479957/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11160
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