Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synt...

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Bibliographische Detailangaben
Hauptverfasser: Kaneko, K, Peretz, D, Pan, K M, Blochberger, T C, Wille, H, Gabizon, R, Griffith, O H, Cohen, F E, Baldwin, M A, Prusiner, S B
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40591/
https://ncbi.nlm.nih.gov/pubmed/7479957
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