Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synt...

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Bibliografiske detaljer
Main Authors: Kaneko, K, Peretz, D, Pan, K M, Blochberger, T C, Wille, H, Gabizon, R, Griffith, O H, Cohen, F E, Baldwin, M A, Prusiner, S B
Format: Artigo
Sprog:Inglês
Udgivet: 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC40591/
https://ncbi.nlm.nih.gov/pubmed/7479957
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