Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.

Conversion of the cellular isoform of prion protein (PrPC) into the scrapie isoform (PrPSc) involves an increase in the beta-sheet content, diminished solubility, and resistance to proteolytic digestion. Transgenetic studies argue that PrPC and PrPSc form a complex during PrPSc formation; thus, synt...

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Bibliographic Details
Main Authors: Kaneko, K, Peretz, D, Pan, K M, Blochberger, T C, Wille, H, Gabizon, R, Griffith, O H, Cohen, F E, Baldwin, M A, Prusiner, S B
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC40591/
https://ncbi.nlm.nih.gov/pubmed/7479957
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