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Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease
Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149175/ https://ncbi.nlm.nih.gov/pubmed/11483499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.15.3957 |
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