Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...

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Detalhes bibliográficos
Main Authors: Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149175/
https://ncbi.nlm.nih.gov/pubmed/11483499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.15.3957
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