Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...

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izdano v:	EMBO J
Principais autores:	Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2001
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.3957
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