Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberrant conformation of the cellular prion protein (PrP(c)). We show that the chemical compound Suramin induced aggregation of PrP in a post-ER/Golgi compartment and prevented further trafficking of PrP(c) to the ou...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Gilch, Sabine, Winklhofer, Konstanze F., Groschup, Martin H., Nunziante, Max, Lucassen, Ralf, Spielhaupter, Christian, Muranyi, Walter, Riesner, Detlev, Tatzelt, Jörg, Schätzl, Hermann M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149175/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.3957
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