The N-Terminal, Polybasic Region of PrP(C) Dictates the Efficiency of Prion Propagation by Binding to PrP(Sc)

Prion propagation involves a templating reaction in which the infectious form of the prion protein (PrP(Sc)) binds to the cellular form (PrP(C)), generating additional molecules of PrP(Sc). While several regions of the PrP(C) molecule have been suggested to play a role in PrP(Sc) formation based on...

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Main Authors: Turnbaugh, Jessie A., Unterberger, Ursula, Saá, Paula, Massignan, Tania, Fluharty, Brian R., Bowman, Frederick P., Miller, Michael B., Supattapone, Surachai, Biasini, Emiliano, Harris, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433751/
https://ncbi.nlm.nih.gov/pubmed/22745483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1103-12.2012
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