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Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation
The infectious agent in prion diseases consists of an aberrantly folded isoform of the cellular prion protein (PrP(c)), termed PrP(Sc), which accumulates in brains of affected individuals. Studies on prion-infected cultured cells indicate that cellular cholesterol homeostasis influences PrP(Sc) prop...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
SP Birkhäuser Verlag Basel
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777232/ https://ncbi.nlm.nih.gov/pubmed/19823766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-009-0158-4 |
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