Anti-Prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein through Disrupting Recycling Propagation of PrP(Sc) and Targeting PrP(Sc) for Lysosomal Degradation

PrP(Sc) is an infectious and disease specific conformer of the prion protein, which accumulation in the CNS underlies the pathology of prion diseases. PrP(Sc) replicates by binding to the cellular conformer of the prion protein (PrP(C)) expressed by host cells and rendering its secondary structure a...

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Bibliographic Details
Published in:Mol Neurobiol
Main Authors: Pankiewicz, Joanna E., Sanchez, Sandrine, Kirshenbaum, Kent, Kascsak, Regina B., Kascsak, Richard J., Sadowski, Martin J.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326903/
https://ncbi.nlm.nih.gov/pubmed/29987703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1208-4
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