Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo

The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrP(C)) into a toxic, infectious, and self-replicating conformer termed PrP(Sc). Following extracerebral inoculation, the replication of PrP(Sc) is confined for months to years to the lymporetic...

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Detalhes bibliográficos
Main Authors: Sadowski, Martin J., Pankiewicz, Joanna, Prelli, Frances, Scholtzova, Henrieta, Spinner, Daryl S., Kascsak, Regina B., Kascsak, Richard J., Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713020/
https://ncbi.nlm.nih.gov/pubmed/19385058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2009.01.013
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