High Titers of Mucosal and Systemic anti-PrP Antibodies Abrogates Oral Prion Infection in Mucosal Vaccinated Mice

Significant outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrP(C), to a toxic and infectious form, PrP(Sc). None of the prionoses currently have an e...

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Autori principali: Goñi, Fernando, Chabalgoity, Jose A., Prelli, Frances, Schreiber, Fernanda, Scholtzova, Henrieta, Chung, Erika, Kascsak, Richard, Kascsak, Regina, Brown, David R., Sigurdsson, Einar M., Wisniewski, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474749/
https://ncbi.nlm.nih.gov/pubmed/18407424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.02.051
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