High Titers of Mucosal and Systemic anti-PrP Antibodies Abrogates Oral Prion Infection in Mucosal Vaccinated Mice

Significant outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrP(C), to a toxic and infectious form, PrP(Sc). None of the prionoses currently have an e...

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Main Authors: Goñi, Fernando, Chabalgoity, Jose A., Prelli, Frances, Schreiber, Fernanda, Scholtzova, Henrieta, Chung, Erika, Kascsak, Richard, Kascsak, Regina, Brown, David R., Sigurdsson, Einar M., Wisniewski, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474749/
https://ncbi.nlm.nih.gov/pubmed/18407424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.02.051
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