Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrP(Sc)-like Folding of Recombinant PrP Amyloids

The structure of the infectious form of prion protein, PrP(Sc), remains unclear. Most pure recombinant prion protein (PrP) amyloids generated in vitro are not infectious and lack the extent of the protease-resistant core and solvent exclusion of infectious PrP(Sc), especially within residues ∼90–160...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Groveman, Bradley R., Kraus, Allison, Raymond, Lynne D., Dolan, Michael A., Anson, Kelsie J., Dorward, David W., Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294479/
https://ncbi.nlm.nih.gov/pubmed/25416779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619627
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados