Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrP(Sc)-like Folding of Recombinant PrP Amyloids

The structure of the infectious form of prion protein, PrP(Sc), remains unclear. Most pure recombinant prion protein (PrP) amyloids generated in vitro are not infectious and lack the extent of the protease-resistant core and solvent exclusion of infectious PrP(Sc), especially within residues ∼90–160...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Groveman, Bradley R., Kraus, Allison, Raymond, Lynne D., Dolan, Michael A., Anson, Kelsie J., Dorward, David W., Caughey, Byron
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4294479/
https://ncbi.nlm.nih.gov/pubmed/25416779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.619627
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