Prion Protein Prolines 102 and 105 and the Surrounding Lysine Cluster Impede Amyloid Formation

Human prion diseases can have acquired, sporadic, or genetic origins, each of which results in the conversion of prion protein (PrP) to transmissible, pathological forms. The genetic prion disease Gerstmann-Straussler-Scheinker syndrome can arise from point mutations of prolines 102 or 105. However,...

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Vydáno v:J Biol Chem
Hlavní autoři: Kraus, Allison, Anson, Kelsie J., Raymond, Lynne D., Martens, Craig, Groveman, Bradley R., Dorward, David W., Caughey, Byron
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571877/
https://ncbi.nlm.nih.gov/pubmed/26175152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665844
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