Prion Protein Prolines 102 and 105 and the Surrounding Lysine Cluster Impede Amyloid Formation

Human prion diseases can have acquired, sporadic, or genetic origins, each of which results in the conversion of prion protein (PrP) to transmissible, pathological forms. The genetic prion disease Gerstmann-Straussler-Scheinker syndrome can arise from point mutations of prolines 102 or 105. However,...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kraus, Allison, Anson, Kelsie J., Raymond, Lynne D., Martens, Craig, Groveman, Bradley R., Dorward, David W., Caughey, Byron
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571877/
https://ncbi.nlm.nih.gov/pubmed/26175152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.665844
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