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Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids

Structures of the infectious form of prion protein (e.g. PrP(Sc) or PrP-Scrapie) remain poorly defined. The prevalent structural models of PrP(Sc) retain most of the native α-helices of the normal, noninfectious prion protein, cellular prion protein (PrP(C)), but evidence is accumulating that these...

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Bibliografiska uppgifter
Huvudupphovsmän: Groveman, Bradley R., Dolan, Michael A., Taubner, Lara M., Kraus, Allison, Wickner, Reed B., Caughey, Byron
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148845/
https://ncbi.nlm.nih.gov/pubmed/25028516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578344
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