Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid

The [PSI+] prion is a self-propagating amyloid of the translation termination factor, Sup35p, of Saccharomyces cerevisiae. The N-terminal 253 residues (NM) of this 685-residue protein normally function in regulating mRNA turnover but spontaneously form infectious amyloid in vitro. We converted the t...

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Bibliografiske detaljer
Main Authors: Gorkovskiy, Anton, Thurber, Kent R., Tycko, Robert, Wickner, Reed B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217437/
https://ncbi.nlm.nih.gov/pubmed/25313080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417974111
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